Petrea Facey

B.Sc. Special Chemistry, UWI Mona Ph.D. Chemistry, UWI, Mona and Alexander von Humboldt Fellowship, University of Göttingen, Germany

Research Interests
Endophytes are bacterial or fungal microorganisms, which spend the whole or part of their life cycle inside the healthy tissues of the host plant, typically causing no apparent symptoms of the disease. The relationship between the endophyte and its host plant may range from latent phytopathogenesis to mutualistic symbiosis. That is, the endophytes get nutrition and protection from the host plant and in return, they protect the host plant by producing certain functional metabolites. Mangrove plants are of interest as they are assemblages of salt-tolerant coastal trees which widely found along the Jamaican coasts.
Our research focuses on the investigation of endophytic fungi associated with these mangroves as well as other endemic plants for the presence of novel and/or interesting biologically active compounds. Emphasis is placed on fungal extracts with antibacterial, antioxidant and anticancer activities. These extracts are subjected to activity-guided isolation studies in order to locate the bioactive components. The purified compounds are then further characterized using modern spectroscopic methods such as 1D and 2D NMR, infrared spectroscopy and where possible, single crystal X-ray crystallography. In addition, new insights into the ecological role of the mangrove-fungal interactions are obtained.
Selected Publications
1. Talontsi, F.M; Facey, P.; Tatong, M.D.K.; Islam, Md. T.; Frauendorf, H.; Draeger, S.; von Tiedemann, A.; Laatsch, H. “Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp. of Zanthoxylum leprieurii.” Phytochemistry, 2012, 83, 87-94.
2. Talontsi, F. M.; Islam, Md. T.; Facey, P.; Douanla-Meli, C.; von Tiedemann, A.; Laatsch, H. “Depsidones and other constituents from Phomopsis sp. CAFT69 and its host plant Endodesmia calophyllolide with potent inhibitory effect on motility of zoospores of grapevine pathogen Plasmopara viticola.” Phytochemistry Letters, 2012, 5, 657-664.
3. McCook-Russell, K. P.; Nair, M. G.; Facey, P. C.; Bowen-Forbes, C. S. “Nutritional and nutraceutical comparison of Jamaican Psidium cattleianum (strawberry guava) and Psidium guajava (common guava) fruits.” Food Chemistry, 2012, 134, 1069–1073.
4. McNeil, M.; Facey, P.; Porter, R. “Essential oils from the Hyptis genus-a review (1909-2009).” Nat. Prod. Commun. 2011, 6, 1775-96.
5. Facey, P. C.; Peart, P.; Porter, R. B. “Antimicrobial activities of Mikanolide and its derivatives.” West Indian Med. J., 2010, 59, 249-252.
6. Vouffo, B.; Dongo E.; Facey, P.; Thorn, A.; Sheldrick, G.; Laatsch, H. “Antiarol cinnamate and Africanoside, a cinnamoyl triterpene and a hydroperoxy-cardenolide from the stem bark of Antiaris Africana (Moraceae).” Planta Med., 2010, 76, 1717-1723.
7. Shaaban, K. A.; Shaaban, M.; Facey, P.; Fotso, S.; Helmke, E.; Laatsch, H. “ γ-Butyrolactone and Electrospray Ionization-Mass Spectra of Piperazimycins A-B from Marine-derived Actinomycete sp.” J. Antibiot., 2008, 61, 736-746.
8. Junor, G-A.; Porter, R.; Facey, P.; Yee, T. “Investigation of the Essential oils extracts from four native Jamaican species of Bursera for Antibacterial activity.” West Indian Med. J. 2007, 56, 22-25.
9. Facey, P. C.; Porter, R. B.; Reese, P. B.; Williams, L. A. D. “Biological activity and Chemical composition of essential oils from Jamaican Hyptis verticillata.” J. Agri. Food Chem., 2005, 52, 4774-4777.
10. Bakir, M.; Facey, P.; Hassan, I.; Mulder, W.; Porter, R. “Mikanolide from Jamaican Mikania micrantha.” Acta Cryst. 2004, C60, o798-o800.
11. Facey, P. C.; Porter, R. B.; Pascoe, K. O.; Jones, A. “Investigation of Jamaican folk-medicine for antibacterial activity.” J. Pharm. Pharmacol., 1999, 51, 1455-1460.
Chapter in Books:
1. Bartnik, M and Facey, P. (2016): Glycosides. In: Pharmacognosy: Fundamentals, Applications and Strategy; Badal McCreath, S., Delgoda, R., Eds.; Elsevier, Philadelphia, USA, pp 101-161.
2. Facey, P. C.; Porter, R. B.; Williams, L. A. D. (2006): The Insecticidal Activity and Chemical Composition of the Essential Oils from Jamaican Hyptis capitata Jacq. In: Biologically Active Natural Products for the 21st Century; Williams, L.; Reese, P.; Eds.: Research SignPost, Trivandrum, India, pp 13-19.