Zika Virus is neurotropic. We report two children from the Caribbean Island of Grenada, a three-year-old with acute neuro-inflammation who had intractable seizures, meningo-enceph-alitis, cerebrospinal fluid (CSF) pleocytosis and Zika Immunoglobulin M (IgM) positive acute serology and a four-year-old with acute demyelinating encephalomyelitis manifesting as generalized seizures, optic neuritis, diffuse cerebral dysfunction, encephalopathy, impaired speech and ataxia who also had CSF pleocytosis as well as Zika IgM and Dengue IgM positive acute serologies.

Background: Dengue fever is hyper-endemic in Jamaica with exponential rates of infection in successive outbreaks. The absence of local data and the potential for massive outbreaks in a country where a third of the population are children formed the basis for this study. 

Background: Chikungunya virus entered the Caribbean for the first time in 2013 and Jamaica experienced its maiden epidemic with Chikungunya fever in 2014. We aimed to describe the public health effects and describe the clinical features in children and adolescents in Jamaica.

Background: Jamaica, along with the Americas, experienced major epidemics of arboviral diseases transmitted by the Aedes aegypti mosquito in recent years. These include: Dengue fever in 2012, Chikungunya fever in 2014 and Zika virus infection (ZIKV) in 2016. We present the emergence of the ZIKV epidemic in Jamaica and outline the national response.