Zinc-infused bioactive glass-ceramic nanoparticles (BGC-NPs) are promising materials for medical applications, particularly in tissue healing and regeneration, due to their biodegradability and bioactivity. This study explores their fabrication, properties, and potential uses. Using advanced techniques, spherical, evenly distributed BGC-NPs were produced and analyzed. The inclusion of zinc facilitated the formation of a hydroxyapatite-like layer, vital for bone healing, in simulated body fluid (SBF). The particles also exhibited biocompatibility, causing minimal damage to blood cells (<5%) and promoting cell migration, essential for tissue repair. Additionally, they enhanced the growth of bone-like cells (MG-63) and demonstrated antibacterial efficacy, particularly against Gram-negative bacteria. These findings highlight the potential of zinc-enriched BGC-NPs for bone regeneration and infection prevention in medical treatments. 

Reference: A. Prasad; A. Maha Lakshmi,  Sathaiah Murimadugula,  P. Venkateswara Rao, Kusum Kumari, Mutlu Özcan, Narayanan Madaboosi, “Hydroxyapatite layer evolution on silica-based (45S10P) bioactive glassceramic nanoparticles doped with Zn2+ ions: Augmentation of in vitro bioactivity, antibacterial activity and textural modification for bone regeneration”

Photo caption:  Dr. Venkateswara Penugonda, Head, Department of Physics Faculty of Science and Technology, The UWI Mona.

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