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Is There an Association between Vitamin D Level and Microvascular Complications of Type 2 Diabetes Mellitus?



Objective: Vitamin D deficiency is associated with impaired glucose tolerance and the development of Type 1 and 2 diabetes mellitus.The aim of this study was to compare the 25-hydroxyvitamin D (25-OH-vitamin D) levels between Type 2 diabetic patients with and without microvascular complications and healthy subjects to identify any possible associations with vitamin D levels and microvascular complications.

Methods: One hundred and one patients with microvascular complications (nephropathy, retinopathy or neuropathy), 102 patients without microvascular complications and 81 healthy subjects were compared in terms of serum levels of 25-OH-vitamin-D, calcium, phosphorus, parathyroid hormone (PTH), and glycated haemoglobin (HbA1c).

Results: No significant differences were found among the three groups with respect to serum calcium, phosphorus and PTH levels, and no correlation was identified between HbA1c and 25-OH-vitamin D levels. The healthy group had higher vitamin D levels than both diabetic groups, while the vitamin D levels were similar in the diabetic groups.

Conclusion: Although vitamin D deficiency is more common in patients with Type 2 diabetes mellitus than healthy subjects, no relationship between vitamin D deficiency and microvascular complications of diabetes was found.


June 1, 2015
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