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The Incidence of Cardiac Lesions among Children with Down’s Syndrome in Jamaica - A Prospective Study

Journal Authors: 
Issue: 
DOI: 
10.7727/wimj.2013.216
Pages: 
693–7

ABSTRACT

Objectives: This study aimed to define the incidence of Down’s syndrome and to describe the epidemiology of cardiac lesions in Jamaican children with Down’s syndrome.

Study Design: A prospective study was conducted on 53 infants during the period January 1, 2007 to December 31, 2007, at the Bustamante Hospital for Children, Kingston, Jamaica. A medical history, physical examination and echo Doppler was performed on each child.

Results: Forty-six thousand babies were born in Jamaica in 2007, of which 53 infants were diagnosed with Down’s syndrome, giving an incidence of 1:868.  Forty-two (79.2%) infants had congenital heart lesions. Of the 42 patients with cardiac lesions, 50% had an isolated cardiac lesion while 50% had multiple defects. The most common single defect was the atrioventricular septal defect found in 10 (24%) patients. The most frequent concomitant malformation was a patent ductus arteriosus, found in 16 (38.1%) of the patients. The median age of diagnosis with Down’s syndrome was 0.14 weeks (interquartile range (IQR) 0 to 68 weeks). The median age of diagnosis with the cardiac lesion was 15.1 weeks (IQR 0 to 40.0 weeks).

Conclusions: The incidence of Down’s syndrome in Jamaica is similar to the reported international experience. The distribution of cardiac malformations is similar to other countries; however, the main difference is the higher incidence of congenital heart disease and a higher incidence of combined lesions.   

Accepted: 
11 Dec, 2013
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Weight: 
-9
e-Published: 26 Aug, 2014
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