This study was aimed to determine the possible therapeutic effects of tadalafil, a specific PDE5 inhibitor, on renal fibrosis induced by unilateral ureteral obstruction (UUO). Our results suggested that tadalafil treatment ameliorated renal fibrosis by reducing TGF-β expression and might have important clinical relevance since tadalafil is currently used clinically to treat erectile dysfunction and pulmonary hypertension.

The research study deals with the antibacterial and antifungal activities of compounds isolated from aerial parts of Gymnosporia royleana by using selected bacterial and fungal species and employing macrodilution method for determination of MIC.

Among clinic attendees the most popular perceived methods for promoting tobacco cessation were joining a Tobacco Cessation clinic (n=23), followed by Quitting on your own (n=13) and seeing a Physician (n=8). Willpower (n=11) was cited as the most common method that assisted in smoking cessation.

In the current investigation, we have made an effort to scientifically validate Gymnosporea royleana's traditional use in various pathological conditions such as antimicrobial, antidiabetic, antioxidant, anticancer and haemagglutination, which could be attributed to the phenolic content of the extract.

In impaired glucose tolerance patients, administration of linagliptin during three months decreased glucose levels at 90 and 120 minutes after a 75-g oral dextrose load and area under the curve of glucose, meanwhile metformin just decreased insulin at 0 minutes.

The vast majority of available evidence on the efficacy, effectiveness and safety of hydroxyurea in childhood sickle cell anaemia (SCA) is mostly from high-income countries. The conclusions drawn from this study would be useful in guiding hydroxyurea use in other less developed countries with limited resources.