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Sperm Quality as a Prognosticator in Intrauterine Insemination-treated Sub-Fertile Saudi Patients

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Background: Intrauterine Insemination (IUI) stays as the most feasible infertility treatment, yet its success indications need further refinement.

Objective: This study aims to determine the most effective sperm parameters that help in prescribing IUI for infertility treatment within a Saudi population sample.

Method: We prospectively studied the inseminated post-wash total motile sperms count (TMSC), and the percentages of the fast(A)-plus-moderate(B)sperm progression of the specimens used for the IUI-treated infertility patients compared with the pregnancy rates (PR) corresponding to those parameters among a Saudi group of infertile patients.

Results: Our results showed clearly that over ten millions of TMSC would significantly make a better chance for conception after IUI-treatment (P=0.034). However, when the TMSC was sixty millions or more the chances for conception became significantly higher (P= 0.007). The A+B progression percentage did not significantly affect the PR (P=0.295). The minimal post-wash TMSC that resulted in conception was 0.5 million sperms, with A+B of 55%, while the minimal post-wash A+B progression percentage that resulted in conception was 25%, with TMSC of 8 million.

Conclusions: Although the semen quality of the studied population is declining, yet the TMSC is still the eligibility determining factor for IUI treated sub-fertile couples. A TMSC of at least ten million is still the recommended number for IUI suitability although as less as 0.5 million still maintains the conception possibilities if the progression and morphology are normal.

10 Aug, 2015
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e-Published: 11 Aug, 2015


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