Objective: To investigate the relationship between both disease activity and the involvement of Behçet’s disease (BD), and serum levels of interleukin (IL)-17 and IL-23.
Methods: Sixty patients with BD and 20 healthy controls were included in this study. Patients were divided into four groups, according to clinical findings, as follows: entero-Behçet, mucocutaneous-Behçet, neuro-Behçet, or vascular-Behçet. Serum IL-17 and IL-23 levels were evaluated using enzyme-linked immunosorbent assay (ELISA).
Results: Of the BD patients, 15 (25%) had active disease and 45 (75%) had inactive disease. Serum levels of IL-23 and IL-17 were significantly higher in patients with BD than in the control groups (p < 0.05). A significant relationship was also observed between disease activity and both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels (p < 0.05). Mean serum levels of IL-17 and IL-23 in patients with active disease were 0.07 ± 0.25 pg/ml and 36.0 ± 30.5 pg/ml, respectively. There was no statistically significant relationship between disease activity and serum levels of IL-17 and IL-23 (p > 0.05). There were also statistically significant relationships between disease activity and uveitis, retinal vasculitis or superficial tromboflebitis.
Conclusions: No relationship was found between Behçet’s disease and serum levels of IL-17 and IL-23. However, levels of IL-23 tended to be higher in patients with active disease.
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