Close Menu

The Relationship between Serum IL-17 and IL-23 levels, and other Disease Activity Parameters in Patients with Behçet’s Disease



Objective: To investigate the relationship between both disease activity and the involvement of Behçet’s disease (BD), and serum levels of interleukin (IL)-17 and IL-23.  

Methods: Sixty patients with BD and 20 healthy controls were included in this study. Patients were divided into four groups, according to clinical findings, as follows: entero-Behçet, mucocutaneous-Behçet, neuro-Behçet, or vascular-Behçet. Serum IL-17 and IL-23 levels were evaluated using enzyme-linked immunosorbent assay (ELISA).

Results: Of the BD patients, 15 (25%) had active disease and 45 (75%) had inactive disease. Serum levels of IL-23 and IL-17 were significantly higher in patients with BD than in the control groups (p < 0.05). A significant relationship was also observed between disease activity and both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels (p < 0.05). Mean serum levels of IL-17 and IL-23 in patients with active disease were 0.07 ± 0.25 pg/ml and 36.0 ± 30.5 pg/ml, respectively. There was no statistically significant relationship between disease activity and serum levels of IL-17 and IL-23 (p > 0.05). There were also statistically significant relationships between disease activity and uveitis, retinal vasculitis or superficial tromboflebitis.

Conclusions: No relationship was found between Behçet’s disease and serum levels of IL-17 and IL-23. However, levels of IL-23 tended to be higher in patients with active disease.

20 Aug, 2015
e-Published: 18 Sep, 2015


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page