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Use of Cystatin C in the Early Diagnosis of Contrast-induced Nephropathy

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Objective: The aim of this study was to explore the application values of Cystatin C (cys-C) in the early diagnosis of contrast-induced nephropathy (CIN).

Methods: 300 patients, who were performed the percutaneous coronary intervention (PCI) with non-ionotropic or iso-osmotic contrast agent, were selected and detected the levels of Cys C and serum creatinine (Scr) at the 4 time points: before PCI, 24 h, 48 h and 72 h after PCI. Acording to the occurrence of CIN within 72 h of opacification, the patients were divided into the CIN group and non-CIN group, and the changes of Cys C and Scr at different time points between the 2 groups were compared. And the Roc curve was used to compare the early diagnostic values of the 2 indicators towards CIN.

Results: Among the 300 patients, 35 cases occurred CIN, with the incidence rate as 11.67%, the postoperative 24 h Cys C level of the CIN group was significantly increased than the non-CIN group, while the Scr level increased at the postoperative 48 h. The area under the ROC curve of postoperative 24 h Cys C was bigger htan that of Scr (0.898 vs 0.885, P = 0.001). The sensitivity of cys-C as the CIN diagnostic standard was 85.7%, with the specificity as 82.4%.

Conclusions: The post-opacification 24 h serum Cys C concentration exhibited certain significance towards the early diagnosis of CIN, and worthy of clinical generalization.

23 Mar, 2015
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e-Published: 16 Oct, 2015


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