Objectives: The aim of this study is to evaluate the variation of cardiovascular risks of subclinical hypothyroid patients with thyroid hormone replacement therapy by using Framingham Risk Scoring system.
Materials and methods: In this study 21 subclinical hypothyroid and 22 healthy volunteers, between the ages 37 to 68 were taken as case and control groups. Subclinical hypothyroid patients were given L-T4 replacement therapy for one year to keep the TSH values in normal ranges. Before and after the treatment clinical and laboratory parameters compared with each other for case and control groups.
Results: When we compared the pre and post treatment values of subclinical hypothyroid patients; The systolic and diastolic blood pressures, total cholesterol, LDL cholesterol levels and framingham risk scores obviously decreased (p<0.05). Although, at the begining of the study ten year cardiovacular risk of the case group was significantly higher than that of control group, after treatment no difference was found between the two groups (p<0.05 vs p>0.05).
Conclusion: By using Framingham Risk Score, its obviously seen that in subclinical hypothyroid patients, just by thyroid hormone replacement therapy a marked decrease of cardiovascular risk can be obtained.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.