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The Effect of Three Different Applications on Rocuronium Injection Pain: A Double Blinded, Randomized Clinical Study



Background: Some agents such as rocuronium and propofol induce severe and noxious pain when administered intravenously during anesthesia induction. This causes to additional stress for the patient who is already stressful due to operation. The purpose of our study was to compare the effects of remifentanyl with two different administration methods and lidocaine on rocuronium injection pain.

Methods: This prospective, double blind, randomized study is designed with 120 patients aged between 17 and 70 years old, American Society of Anesthesiologists (ASA) physical status I-II, undergoing different elective surgery types that require muscle relaxation. Patients were randomly distributed to 3 groups; Group 1 (remifentanyl-bandaged, n=40), Group 2 (lidocaine-bandaged, n=40) and Group 3 (remifentanyl non-bandaged, n=40). Mean arterial pressure and pulse rate were recorded before induction, 1 minute after induction and after intubation. An independent anesthetist blind to groups assessed and recorded Verbal Rating Scale.

Results: There were no significant differences between groups regarding demographic variables. Cardiovascular hemodynamics regarding mean arterial pressure and pulse did not change significantly between groups before and after induction and after intubation. Pain scores were comparable between groups.

Conclusion: Remifentanyl can be used either with venous occlusion or as intravenous bolus to prevent rocuronium induced pain with no significant difference and it is as effective as lidocaine. 

18 May, 2015
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e-Published: 11 Nov, 2015


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