ABSTRACT
Objective: Systemic lupus erythematosus (SLE) is a connective tissue disease with chronic and recurrent and inflammatory progression. Antiinflammatory cytokines such as adiponectin change in this disease like other inflammatory diseases. This study aimed to evaluate the relationship between urinary and serum level of Adiponectin with disease activity in patients with SLE.
Methods and materials: In this case-control study, 80 women referred to the rheumatology clinic of 5 Azar Hospital in Gorgan, divided to case and control group. Then urinary and serum level of adiponectin measured by ELISA kit and disease activity evaluated by SLE disease activity index were Blood samples were taken from both groups and serum levels of interleukin -2 measured by AviBion human IL-2. Data analysis conducted by SPSS software (version 16) and by using descriptive statistics and statistical tests.
Results: Mean serum level of adiponectin in case group had statistically significant association with control group (p < 0.001) and mean urinary adiponectin level in case group had statistically significant correlation with control group too (p < 0.035). Only serum level of adiponectin was significantly associated with SLE disease activity index in case group (r = 0.63, p < 0.0001) and urinary level of adiponectin was significantly associated with renal involvement (r = 0.59, p < 0/0001).
Conclusions: Findings of the present study showed the relationship between serum level of Adiponectin with disease activity in patients with SLE. So this biomarker can be used for effective treatment and decrease of complications.
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