ABSTRACT
Objective: Allergic rhinitis (AR) may cause neurobehavioural symptoms and impair quality of life (QoL). We evaluated the efficacy of AR treatment on QoL, attention deficit and hyperactivity symptoms in paediatric allergic rhinitis.
Methods: Twenty five children with grass pollen-sensitized seasonal AR were enrolled. They completed the Total 4-Symptom Score (T4SS), and Paediatric Rhinitis Quality of Life Questionnaire (PRQLQ). Conners' Parent Rating Scale-48 (CPRS) questionnaire was completed by the mothers to identify attention deficit and hyperactivity symptoms in children with AR. The patients were given fluticasone furoate (FF) nasal spray 27.5 microgr once daily and levocetirizine dihydrochloride (LD) 5 mg oral tablet once daily for six weeks. After six weeks, T4SS, PRQLQ and CPRS were repeated in AR group. The mothers of thirty four healthy children completed CPRS questionnaire as control group.
Results: After treatment, T4SS and PRQLQ scores improved in AR group (p = 0.001). Pre-treatment attention deficit and hyperactivity scores in AR group were higher than those in the control group (p = 0.001, 0.009, respectively). After treatment, attention deficit scores improved in AR group, and there were no differences in attention deficit scores between two groups, and hyperactivity scores in AR group were lower than those in control (p = 0.785, 0.007, respectively).
Conclusions: AR may show negative effect on QoL and neurobehavioural health of the patients. The combination treatment of FF nasal sprey and LD tablet may improve nasal symptoms, QoL, attention deficit and hyperactivity symptoms.
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