Close Menu

Books in a Library

Correlation between Anaemia and Hepcidin-25 and Interleukin 6 Levels in Early Stage and Advanced Chronic Renal Disease



 Background: Anemia is very commonly seen complication in the patients with chronic renal disease (CRD). This is thought to result from decreased renal excretion of the hepcidin and chronic inflammatory process. Our study aimed to investigate the correlation between hemoglobin (Hb) and hepcidin levels in all stages starting from stage 2 CRD.

Method: The study was conducted on a total of 80 patients with stage 2-3-4-5 chronic renal disease who have not been treated with renal replacement therapy, including 20 patients from each stage. In all groups, C-reactive protein (CRP), high sensitivity C-reactive protein (HsCRP), interleukin 6 (IL 6), hepcidin-25, routine biochemistry, whole blood count, iron, total iron binding capacity (TIBC), ferritin, folic acid and Vitamin B12 were measured.

Results: When the patients were evaluated for inflammatory parameters, CRP (p=0.01), HsCRP (p=0.01), erythrocyte sedimentation rate (ESR) (p=0.001), IL 6 (p=0.001), ferritin (p=0.02), hepcidin-25 (p=0.03) levels were significantly higher in the group with advanced stage compared to the group with early stage. It was determined that hemoglobin (Hb) level was statistically significantly lower in advanced CRD compared to early stage CRD (p<0.001).

Conclusion: Using the agents that may decrease the levels of hepcidin may be useful to increase Hb levels in the treatment of anemia in the patients with chronic renal disease.


21 Aug, 2015
PDF Attachment: 
e-Published: 22 Jan, 2016


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page