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Ovarıan Granulosa Cell Tumors: Evaluatıon of Clınıcal, Outcome and Reccurence Factors

DOI: 
10.7727/wimj.2015.354

ABSTRACT

Objective: We aimed to determine the predictors for poor prognosis and to find out the effect of treatment strategies on survival functions

Methods: Thirty seven women with granulosa cell tumor were enrolled for the study between 2000 and 2013. All data was obtained from hospital prospectively collected databese.

Results: The mean age was 50.1±13.3 and the most common symptom was abdominal distansion ( 21.6%) . Mean follow up period was 67.9±33.6 months.  During follow up period

Disease specific mortality was observed in only 1 (2.7%) patient and recurrence was observed in 7 patients (18.9 %).  Comparison of the groups with and without recurrence revealed significant differences in terms of stage, capsule involvement, mitotic index between groups (p<0.05). In multivariate regression analyses tumor differentiation was found to be significantly associated with the disease recurrence (OR:8.2,CI 95%: 0,019-0,771).

Conclusion: Tumor differentiation is found to be a significant confounder for the disease recurrence after adjustment for the   stage.

Accepted: 
07 Sep, 2015
PDF Attachment: 
e-Published: 28 Jan, 2016

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