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The Effect of Continuous Positive Airway Pressure on Basal Metabolism Rate in Patients with Severe Obstructive Sleep Apnea Syndrome



Objectives: The aim of this study was to assess the effect of the continuous positive airway pressure (CPAP) treatment on basal metabolism rate in patients with severe obstructive sleep apnea syndrome (OSAS).

Methods: Demographic characteristics, body-mass index (BMI), apnea-hypopnea index (AHI) and smoking history of the patients were recorded.  Basal metabolism rate was measured via indirect calorimetry in the morning following the nights of polysomnography and CPAP titration. Basal metabolism rate, VO2 and VCO2 levels were compared before and after CPAP administration.

Results: Six (24%) female and 19 (76%) male, totally 25 patients with mean age of 51.4 ± 13.7 years were included into the study. A significant reduction in the basal metabolism rate (p=0.049), VO2 (p=0.042) and VCO2 (p=0.008) values were observed after single night administration of CPAP compared to before treatment. Furthermore, it was detected that this reduction provided by CPAP treatment was more significant in current smokers, patients with AHI>60 and BMI ≥ 30.

Conclusion: It is suggested that there is a correlation between basal metabolism rate and the severity of OSAS and it is possible to provide significant reduction in basal metabolism rate with single night administration of CPAP depending on the patient’s smoking history, degree of obesity and disease severity.


02 Nov, 2016
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e-Published: 08 Feb, 2016

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