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Is Imatinib Protective Against to Osteoporosis? - A Comparative Study in Terms of Bone Densitometry on Chronic Myeloid Leukaemia Patients and Healthy Volunteers

DOI: 
10.7727/wimj.2015.447

ABSTRACTS

Objective: Chronic Myeloid Leukaemia (CML) is a clonal disorder in which cells of the myeloid serie undergo excessive proliferation. The characteristic genetic abnormality of the disease, the Philadelphia (Ph) chromosome, results from a reciprocal translocation between the long arms of chromosomes 9 and 22. The molecular consequence of this translocation is the production of fusion protein bcr-abl. Imatinib is an effective agent in treating CML by targeting the constitutively active tyrosine-kinase domain of bcr-abl. The aim of our study is to determine possible effect of use of imatinib on osteoporosis via comparing dual-energy X-ray absorptiometry (DXA) results of CML group and control group.

Subjects and Methods:This study was performed on 20 patients with CML and 20 people in control group who visited Turgut Ozal Medical Center. Both blood and urine analyses in addition to dual-energy X-ray absorptiometry (DXA) measurements were performed at Turgut Ozal Medical Center, Faculty of Medicine, Inonu University. Mann–Whitney U test were used to compare CML patients and controls. A p < 0.05 was considered statistically significant.

Results: The mean-serum level of phosphate in CML group was found significantly lower than the control group (p < 0.05). The mean-urine calcium level of the patients with hypophosphatemia was found significantly higher (p < 0.05) than the patients with normophosphatemia.

Conclusion: The significant correlation between hypophosphatemia and the use of imatinib which has been determined in our study was harmonious with outcomes of previous studies. However, we did not observe a statistically significant correlation between the use of imatinib and osteoporosis in this study.

Accepted: 
08 Sep, 2015
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e-Published: 12 Feb, 2016

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