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A “Full House” Glomerulopathy in a Patient with Multiple Lentigenes Syndrome: A Case Report



Multiple Lentigines syndrome (MLS) is an autosomal dominant disease which is usually diagnosed clinically by the presence of characteristic features. The molecular genetic testing is an adjuvant diagnostic tool to identify the mutation of particular genes such as PTPN11 genes, RAF1, BRAF or MAP2K1 genes (1-4). This syndrome is formerly known as LEOPARD syndrome or Noonan syndrome with multiple Lentigines (NSML). Leopard Syndrome is an acronym of characteristic features (Lentigines, Electrocardiographic conduction abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormalities of the genitalia, Retardation of growth and Deafness) which was introduced by Grolin and colleagues in 1969 (5). There was no previous case report about any glomerulonephropathy in association with Multiple Lentigines Syndrome. Herein, we present a case of multiple lentigenes syndrome with recurrent nephrotic syndrome who is found to have histologic evidence of full house glomerulopathy. 

11 Jan, 2016
e-Published: 23 Feb, 2016

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