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Platelet Count and Mean Platelet Volume: Supportive Markers in Differentiation of Tuberculosis and Sarcoidosis



Background and Objectives: Tuberculosis and sarcoidosis are two diseases showing  histological and clinicial similarities and differiantial diagnosis of two is still very  challenging.  Platelet count PLT and MPV are new inflammatory markers  investigated in different chronic diseases.  But their role in differiantion of tuberculosis and sarcoidosis is not well known. In present study we aimed to asses platelet count (PLT) and mean platelet volume (MPV)  as  supportive markers in distinction of sarcoidosis and tuberculosis.

Patients and Methods: 100 patients with sarcoidosis, 83 patients with tuberculosis and 36 heathy subjects were included in this restrospective study. Subject’s characteristics, leukocyte (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR),  PLT  and MPV  values were recorded.

Results: Eligible 219 patients were enrolled in present study. CRP, ESR,WBC and PLT values were found higher in tuberculosis patients than  that of  sarcoidosis and control patients. PLT was significantly higher and MPV was lower in tuberculosis group compared to sarcoidosis group. The most appropriate cut-off value of PLT and MPV  to distinguish tuberculosis from sarcoidosis was determined as 300.000 and 8,5 respectively. PLT value above 300.000 and MPV  value below 8,5 were found meaningful to differiantiate tuberculosis from sarcoidosis.

Conclusion: PLT and MPV were found to be supportive markers  in differiantion of tuberculosis and  sarcoidosis.

11 Jan, 2016
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e-Published: 23 Feb, 2016


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