ABSTRACT
Isotretinoin (Iso) is used for the treatment of severe acne, and seronegative sacroiliitis is a rare side effect of this therapy. We present the case of a woman with unilateral sacroiliitis that began during Iso therapy. She had a family history of ankylosing spondylitis (AS) and human leukocyte antigen-B27 (HLA-B27) positivity. Magnetic resonance imaging (MRI) demonstrated acute inflammatory changes in the left sacroiliac joint. The Iso therapy was withdrawn, and after four more weeks, she was symptom-free. One year later, the inflammatory features of sacroiliitis were still preserved. We believe that Iso treatment may have induced or accelerated the emergence of sacroiliitis in patients with HLA-B27 positivity and family history of spondiloarthropathy. Patients should be questioned about their personal and family histories of spondyloarhropathy before being treated with Iso for acne, and alternative treatment modalities should be considered.
Manuscripts that are “Published at Acceptance” have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear prior to being copy edited or formatted in the style guide of this Journal. The contents of the manuscript may change before it is published in its final form. While accepted manuscripts are not yet assigned a volume, issue, or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. Manuscripts in this section will be removed once they have been assigned to a volume and issue, but will still retain the DOI and date of e-publication.
Our 7 faculties and 12 professional schools offer more than 200 programmes to some 18,000 graduate, undergraduate and continuing studies students.
The UWI, Mona ranks first in Jamaica among accredited tertiary-level programmes. In 2012, the University was again one of Jamaica’s Top 100 Employers.
