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A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

DOI: 
10.7727/wimj.2016.025

ABSTRACT

Background: To evaluate the relationship between disease activity and levels of YKL-40 in patients with Behcet’s disease (BD).

Methods: Twenty five active and twenty six inactive BD patients and 24 age and gender matched healthy control subjects were included in the study. Serum YKL-40 levels were measured using Enzyme Linked Immuno Sorbent Assay (ng/mL). Disease activity was assessed using Behcet’s Disease Current Activity Form (BDCAF).

Results: Serum YKL-40 levels were significantly higher in patients with active BD and inactive BD compared to the control group (respectively p<0.001, p< 0.001). There were no significant differences between active and inactive BD groups in terms of levels of YKL-40 (p=0.9). According to Pearson’s analysis, YKL-40 levels were significantly positively correlated with Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and skin lesions of BDCAF scores.

Conclusion: Our study demonstrated that serumYKL-40 level was significantly higher in active and inactive BD compared to healthy controls. However, the groups with active and inactive disease had no significant difference with respect to YKL-40 level. In addition, there existed a significant correlation between serum YKL-40 level and ESR, CRP, and BDCAF’s skin scores. 

Accepted: 
02 Feb, 2016
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e-Published: 01 Mar, 2016

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