Chronic urticaria (CU) is a common disease in which most cases were considered to be idiopathic. This report presents two patients with chronic urticaria who diagnosed papillary thyroid carcinoma. A 50-year-old woman and a 38-year-old woman were admitted to hospital with histories of chronic urticaria on an individual basis. Laboratory results and allergy tests resulted negative. Ultrasound examinations revealed a heterogeneous solid node on the thyroid gland. Fine-needle aspiration biopsies resulted with papillary carcinoma of thyroid. They both underwent total thyroidectomy and completely recovered from their urticarial lesions three and four days later, respectively. Several cases of thyroid malignancies associated with urticaria have been published in the literature. However, the exact mechanisms cause to these disorders concomitantly have not been known yet. These cases give rise to thought a presence of cause and effect relationship between CU and thyroid malignancies. These report may highlite to evalution of some CU patients. Eventhough the laboratory findings are normal, examination of thyroid gland must be done carefully especially in treatment resistant CU patients.
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