Close Menu

The Efficacy of Quadruple Therapy in the Eradication of Helicobacter pylori in Cases of Duodenal Ulcer

DOI: 
10.7727/wimj.2015.516

ABSTRACT

Background: Helicobacter pylori (H. pylori) is an important cause of duodenal ulcer (DU) and eradication this infection can prevent complication related to DU and recurrence of the DU. Quadruple therapy (QT) is one of the recommended treatment regimen for the H. pylori eradication. But there has not been enough data for impact of the QT on eradication success of the H. pylori in patients with DU. We aimed to investigate success of QT in H. pylori positive patients with DU.

Method: We included 140 patients who had DU and histology proven H. pylori infection into the study. All patients were given a quadruple therapy program for 14 days consisting of colloidal bismuth subcitrate 300 mg 2x2; tetracycline hidrochloride 500 mg (qid); metronidazole 500 mg (t.i.d.) and a proton pump inhibitor (PPI) (bid) randomly which esomeprazole 20 mg for patients in group 1 (ETMB), lansoprasol 30 mg for group 2 (LTMB), pantoprazole 40 mg for group 3 (PTMB) and rabeprazole 20 mg for group 4 (RTMB). Eradication rate was measured by urea breath test at least 6 weeks after the end of the treatment

Results: Average eradication rate was 78.8 % in ITT analysis (%95 CI 0. 71-0. 84) and 81.8% in PP analysis for all groups (% 95 CI 0. 74-0. 87). There was no significant differences between different PPI groups.

Conclusion: In patients with DU and H. pylori infection, QT can provide an acceptable but not enough successful eradication success. 

Accepted: 
21 Oct, 2015
PDF Attachment: 
e-Published: 07 Mar, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page