Objective: To explore the correlation analysis of serum N-terminal pro b-type natriuretic peptide (NT-proBNP), potential of hydrogen (pH) value and carbon dioxide (PaCO2) in patients with different degrees of chronic obstructive pulmonary disease (COPD) and their significances.
Methods: Clinical data were collected from 126 patients with chronic obstructive pulmonary disease. The correlation analysis of NT-proBNP, pH-value and PaCO2 in patients was performed and compared with 50 patients of the same period. The serum NT-proBNP concentration was measured by using bidirectional lateral flow immunoassay, pH-value was detected with the ion electrode selection method and PaCO2 was detected with the gas sensitive electrode method.
Results: The concentration of serum NT-proBNP and PaCO2 in COPD patients was significantly higher than those in the healthy group. The pH-value in COPD patients was lower than that in the healthy group (p < 0.05). The concentration of serum NT-proBNP and PaCO2 in Grades 1 and 2 COPD patients was higher than those in the healthy control group. The pH-value was lower than that in the healthy control group. But the difference was not statistically significant (p > 0.05). The concentration of serum NT-proBNP and PaCO2 in Grades 3 and 4 COPD patients were higher than those in the healthy control group. The pH-value was lower than that in the healthy control group (p < 0.05). The linear correlation analysis showed that serum NT-proBNP was negatively correlated with pH-value and positively correlated with PaCO2 in COPD patients.
Conclusion: The regular detection of serum NT-proBNP, pH-value and PaCO2 in COPD patients can detect earlier disease progression in COPD patients, which is conducive to the active treatment of COPD and with change of life style, can improve the quality of life of patients.