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Mediastinal Thymolipoma: An Evaluation of the Clinical and Radiological Features and the Surgical Outcomes in 11 Cases



Background: Thymolipoma is a rare benign tumor of the mediastinum, accounting for 2-9 % of all thymic tumors. Although many case reports have been published in the literature, few studies have analyzed the clinical and radiological features and the surgical outcomes of this tumor.

Aim: To evaluate the clinical and radiological features and the surgical outcomes of the patients with thymolipoma.

Methods: We reviewed the records of pathology department from the beginning of 2005 to the end of 2013.

Results: We identified 11 patients with thymolipoma. There were eight male and three female patients. Their ages ranged from 27 to 72 years, with mean age of 40 years. All patients described pulmonary or extrapulmonary symptoms. Two patients (18.2 %) had myasthenia gravis. Chest X-ray was normal in four patients. Computed tomography of the thorax revealed a mass located in the anterior mediastinum in all patients. It showed fat attenuation in four of 11 patients (36.4 %). Thymectomy was performed in all patients. The surgical approach was thoracotomy in five, sternotomy in four, and video-assisted thoracic surgery in two. Thymolipomas ranged in size from 4 to 33 cm. One patient died two years after surgery. None of remaining patients had evidence of recurrence on follow-up.

Conclusions: Thymolipoma is a rare tumor of the thymus. It may be associated with myasthenia gravis. Surgical resection is the treatment of choice in the patients with thymolipoma. Complete surgical resection is the cure in most patients.

07 Dec, 2015
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e-Published: 29 Mar, 2016


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