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Neutrophil–lymphocyte Ratio: Predictor of High-grade Dysplasia in Colorectal Polyp



Objective: To determine the value of neutrophil–lymphocyte ratio for predicting high-grade dysplasia among patients with neoplastic colorectal polyp.

Method: We evaluated 30 patients with non-neoplastic polyp, 61 patients with neoplastic polyp (32 with high-grade dysplasia/29 without high-grade dysplasia), and 30 patients with normal colonoscopy as control group. Mean platelet volume, red cell distribution width, neutrophil and lymphocyte levels were recorded and neutrophil–lymphocyte ratio was calculated.

Results: Mean neutrophil–lymphocyte ratio of patients with neoplastic polyp were higher than patients with non-neoplastic polyp and control group (2.56 ± 1.47, 1.77 ± 0.44, 1.76 ± 0.62, retrospectively) (p = 0.001). Mean platelet volume of patients with neoplastic polyp (8.76 ± 1.06) was lower than patients with non- neoplastic polyp (9.50 ± 1.27) and control group (10.96 ± 0.83) (p < 0.001). Mean neutrophil–lymphocyte ratio of patients with high-grade dysplasia (3.03 ± 1.88) was significantly higher than patients without high-grade dysplasia (2.14 ± 0.77) (p = 0.022). The cut off value of neutrophil–lymphocyte ratio to predict the presence of highgrade dysplasia was 2.044 (sensitivity: 69%, specificity: 68%).

Conclusion: Neutrophil–lymphocyte ratio, which is a simple non-invasive index can predict high-grade dysplasia and neoplastic polyp. Although mean platelet volume and red cell distribution width are not useful for identifying high-grade dysplasia in patients with colorectal polyp, mean platelet volume may be associated with neoplastic polyp.

07 Jan, 2016
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e-Published: 30 Mar, 2016
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