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Predictive Value of Neutrophil/lymphocyte Ratio for Differentiating Organic Dyspepsia from Functional Dyspepsia



Objective: Dyspepsia, one of the most commonly seen symptoms, can be due to organic dyspepsia (OD) or functional dyspepsia (FD). The aim of this study is to evaluate neutrophil to lymphocyte ratio (NLR) for the predictability of organic dyspepsia due to peptic ulcer disease (PUD) and gastric cancer (GC).

Methods: We investigated retrospectively the dyspepsia patients who underwent endoscopy. The study included 119 patients with organic dyspepsia (41 patients with biopsy proven GC and 78 patients with PUD) and 100 patients with FD diagnosed.

Results: The NLR among the GC and PUD patients were significantly higher than FD subject (p<0.001 each). The NLR in GC patients was also significantly higher than PUD patients (p<0.005). When OD was compared with FD, NLR and WBC was statistically significantly higher (p<0.001 and p<0.05 respectively). The best predictive cut-off value of NLR was 1.72 with a specifity of 63% and sensitivity of 66% for OD, on ROC curve analysis.

Conclusion: NLR was detected higher in OD patients compared with FD, and even higher in patients with GC.  Our findings suggest that NLR should be calculated in patients with dyspepsia and patients with high levels of NLR should undergo endoscopy. 

25 Nov, 2015
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e-Published: 30 Mar, 2016


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