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Occurrence of Plasmid-mediated AmpC β-lactamases among Enterobacter cloacae, Serratia marcescens and Citrobacter freundii in China

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Background: A total of 775 consecutive non-duplicate isolates of Enterobacteriaceae (534 E. cloacae, 137 S. marcescens and 104 C. freundii) were collected from 2005 to 2014 at 34 hospitals in Anhui Province, China.

Material and Methods: The detection of plasmid-mediated AmpC β-lactamases (pAmpCs) was based on the inhibitor screening method. Then, the association with other β-lactamases and mobile genetic elements, like class 1 integron, ISCR1 and ISEcp1, were analyzed by molecular biology method.

Results: Among the total of 775 isolates, the prevalence of pAmpC was discovered to be 8.1% (63/775) overall. In this study, the presence of pAmpCs was significantly linked to other β-lactamases and mobile genetic elements, among which blaCTX-M and class 1 integron were the most prevalent genotype.

Conclusion: Therefore, various combinations of β-lactamases and mobile genetic elements were detected in the study. Plasmids were demonstrated to be the main vehicles for the dissemination of pAmpC genes.

15 Jun, 2016
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e-Published: 29 Jun, 2016


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