Introduction: The Odontogenic Keratocyst is known for its aggressiveness, high recurrence rate and transformation of keratinized epithelia to non-keratinized squamous epithelium for which inflammation has been suggested to be responsible. bcl-2 an anti-apoptotic protein, prolongs the life span of epithelial cells and allows proliferation, differentiation and morphogenesis.
Materials and method: Study was carried out comprising of 90 cases; [30 Ameloblastoma, 30 Keratocystic Odontogenic tumor and 30 Radicular cyst]. Bcl-2 expression was determined with respect to Localization, Area [percentage] and Intensity of stained cells in epithelium and connective tissue stroma by counting the endothelial, round and fusiform cells.
Results: In epithelium bcl-2 expression in Keratocystic Odontogenic tumors was higher followed by Ameloblastoma and lowest in Radicular cyst. Whereas, in connective tissue stroma bcl-2 expression was higher in Keratocystic Odontogenic tumor and Radicular cyst than Ameloblastoma cases. Solid variants showed statistically higher expression as compared to the Unicystic variants of Ameloblastoma [p-value 0.009, 0.033, 0.011, 0.041].
Conclusion: High expression of bcl-2 in KCOT supports the general agreement that some features of OKC are those of a neoplasia. The bcl-2 expression in connective tissue cells suggests that these cells may also be important as epithelial cells in the biological behaviour odontogenic keatocyst.
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