Close Menu

Degenerative Disc Pathology in Patients with Ankylosing Spondylitis: Its Frequency and Relation with Disease Activity

DOI: 
10.7727/wimj.2016.121

ABSTRACT

Objective: To determine the frequency of degenerative disc pathology in patients with ankylosing spondylitis (AS) and explore its association with parameters of disease activity.

Material-Method: Patients between 15 and 65 years of age diagnosed with AS whose lumbar magnetic resonance imaging records were available in registry database were enrolled. A total of 88 patients and 440 discs were evaluated. Modic classification was used for endplate degeneration and Pfirrmann scale and the degree of disc herniation were analyzed for disc degeneration. Aforementioned parameters were evaluated to determine whether they were associated with erythrocyte sedimentation rate (ESR), serum C- reactive protein (CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Values were expressed as frequencies and percentages for categorical variables. Spearman’s test was used for correlation analysis.

Results: Among 440 discs examined, Modic changes were detected in 13% (Person count (PC): 30.7%) and Modic type 2 changes were the most common (Disc Count (DC): 8.9%, PC: % 25). The most frequent Pfirrmann change was grade 1 degeneration (DC: 57.7%, 254 disc) and the most common form of disc herniation was bulgingdir (DC: 21.7%, PC: 67%). A positive correlation was found between L1-L2 disc herniation and BASDAI activity and between L2-L3 disc herniation and CRP level (p<0.05).
Conclusion: A high prevalence of Modic type 2 changes and bulging herniation was found. While this study may provide some insight for degenerative disc disease in AS, further studies involving a larger number of patients and a control group are needed.

Accepted: 
16 Jun, 2016
PDF Attachment: 
e-Published: 21 Jul, 2016

Disclaimer

Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page