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The Role of Cardioselective Beta Blockers in Cardiopulmonary Exercise Test and Echocardiography in COPD Patients



Objective: The aim of this study was to evaluate the effects of cardioselective β-blockers in echocardiography and cardiopulmonary exercise tests (CPET) in COPD patients.

Methods: Patients with COPD admitted to Pulmonary Diseases and Cardiology department between January 2011 and January 2013 were enrolled in this study. Group I included the patients with COPD (n: 26); group II included COPD patients with accompanying heart disease with no use of β-blockers (n: 25); group III included COPD patients with accompanying heart disease treated with cardioselective β-blocker (metoprolol) (n: 22). Age, height, weight and medical history of all patients were recorded; and routine laboratory tests, CPET, and echocardiography were performed. In the first year, the tests were repeated using the same devices and protocols.

Results: There were 73 patients in study, 4 (5.5%) female and 69 (94.5%) male. The average age of the patients was 63±8 years. According to GOLD criteria, 4 (5.5%) patients were in stage 1 COPD, 30 (41.1%) patients in stage 2, 23 (31.5%) patients in stage 3, and 16 (21.9%) patients were in stage 4. The COPD patients with accompanying heart disease (Group II and III) had significantly higher pro-BNP values than group I patients. The basal and final values of echocardiography and CPET after one year did not differ significantly in all study groups (p>0.05).

Conclusions: This study suggests that the cardio-selective β-blockers, which are contraindicated in COPD patients, are safe and do not affect CPET and echocardiography measurements. 

12 Aug, 2016
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e-Published: 12 Aug, 2016


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