ABSTRACT
Objective: Male breast cancer (MBC) is rarely seen in male sex with a prevalence in the general population of approximately 1 per 100,000. Our aim was to determine retrospectively the clinicopathological features and overall survival at 22 male invasive breast carcinoma cases with the molecular sub-types based on immunohistochemistry in nine years period.
Methods: All male patients presenting with invasive breast carcinoma between January 2006 and September 2014 data were recorded regarding age, clinical presentation, operative procedure, tumor size, histologic type, grade, lymph node involvement, immunohistochemical results of HER-2, hormone receptors, Ki-67 and p53 with stage and outcome.
Results: The mean age of the group was 68.05 years with a 72.7% had performed a modified radical mastectomy (MRM). The mean diameter of tumors was 2.63 cm and the most common histologic type was invasive ductal carcinoma (IDC). Notably there was no grade I tumor and Luminal B type had slightly high in number.
Conclusion: We found a significant correlation in between luminal molecular subtype and Ki67 proliferation. The mean overall survival time was 75.3 months. Luminal subtypes were not showed significant difference with overall survival time.
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