ABSTRACT
Objectives: To observe the change of pulmonary artery systolic pressure (PASP) of patients with persistent pulmonary arterial hypertension (PAH) after patent ductus arteriosus (PDA) occlusion.
Background: After occlusion of PDA with PAH, PAH can be persistent in some patients. Methods: A chest x ray, an electrocardiogram and an echocardiogram were performed on all patients at 24 hours, one month, six months and 1 year intervals serially.
Results: There was a significant fall (p＜0.05) in mean PASP after occlusion (to 59.3(12.7)mmHg). However, the aortic pressure and SaO2 changed slightly (p﹥0.05). During the follow up, there was a further fall of PASP in 5 patients (NO 1, 5, 6, 7 and 8). Four patients (NO 2, 3, 4 and 8) showed the evidence of worsening of the PAH and were treated with sildenafil. Patient 2 died from acute right heart failure after a period of 11 months from the time of TCC (Transcatheter closure), triggered by pulmonary infection.
Conclusions: Some patients with borderline hemodynamic data with PDA and PAH can deteriorate or keep sustained PAH after PDA closure. The treatment of permanent closure to these patients must be cautious.
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