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Histopathological Examination of the Effects of Butane Gas on Nasal Mucosa in Rats



Objective: Butane is present as propellant gas in deodorants, shaving foam tubes, air fresheners. In our study, potential allergic effects of chronic inhalation of butane on nasal mucosa of rats were evaluated.

Methods: An experimental study was conducted on Wistar Albino rats. Animals were divided into two groups as experimental and control. Butane was exposed to the experimental group for 100 days. Five micron-thick coronal slices were taken from the nasal cavities of the animals. Eosinophils, goblet cells, lymphocytes and eosinophil exocytosis were evaluated in slices. Results: An increase was found in eosinophil counts in experimental group (p < 0.001), between the groups lymphocyte infiltration, amount of goblet cells and eosinophil exocytosis was found similar (p > 0.05). A positively correlation was observed between lymphocyte infiltration and eosinophil exocytosis in experimental group (p = 0.0001).

Conclusion: According to our study butane may create inflammation in nasal mucosa

01 Sep, 2016
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e-Published: 05 Sep, 2016


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