ABSTRACT
Objective: To determine the risk factors in neonatal necrotizing enterocolitis (NEC) and provide options for the prevention and treatment of NEC.
Methods: Clinical information of 70 newborn infants with NEC, admitted to our hospital between January 2004 and April 2012, were reviewed and analyzed, including clinical characteristics, maternal factors during perinatal period, newborn factors, feeding history, concomitant diseases, antibiotic treatment and prognosis.
Results: The time of onset was 1-28 days (with median of 7 days) after birth and 58 cases (82.9%) suffered from NEC within 14 days of birth. Staging: 21 cases (30%) were stage I (suspected as NEC), 21 cases (30%) were stage II (confirmed as NEC) and 28 cases (40%) were in stage III (severe NEC). Maternal factors during perinatal period, newborn factors, feeding, concomitant diseases and administration of antibiotics, all played a role in the treatment of NEC.
Conclusion: NEC is associated with premature, low birth weight, infection, improper feeding, delay in meconium excretion, accompanied by severe anoxic and ischemic disease and improper antibiotic treatment.
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