ABSTRACT
Objective: To investigate the connection of galectin 3 with HCC risk.
Methods: Publications were searched using PubMed, MEDLINE, EMBASE and the Chinese databases (including CNKI and WanFang) up to October 2015.
Results: A total of four studies were included into this analysis. The combined mean difference suggested that serum Galectin 3 levels tended to be associated with hepatitis 1.98(95% CI: 1.13-2.83, Z=4.57, P<0.00001) and healthy person 2.29(95% CI: 2.09-2.5, Z=21.78, P<0.00001).The serum Galectin3 level in HCC was significant higher than that in hepatitis and healthy person. The pooled sensitivity and specificity were 0.93 (95% CI: 0.86–0.97) and 0.83 (95% CI: 0.74–0.90), the pooled DOR were 116.78 (95% CI: 0.13–102122.46), the pooled positive LR were 12.71 (95% CI: 0.12–1374.27), and the pooled negative LR were 0.11 (95% CI: 0.00–12.51).
Conclusion: The serum Galectin 3 level of HCC is higher than that of hepatitis and healthy person. And the expression of serum Galectin 3 tended to be a bigger possibility biomarker for diagnosis of HCC.
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