ABSTRACT
Objective: The reasons for post-operative cognitive decline (POCD) remain largely unknown. Therefore, we determined the effect of cerebral artery stenosis on post-operative cognitive function in the elderly.
Methods: Eligible patients were between 60 and 80 years of age, and underwent elective, non-cardiac surgery at Beijing Friendship Hospital (Capital Medical University, Beijing, China) in 2013. Neuropsychological tests and transcranial Doppler ultrasound (TCD) were performed in 120 subjects pre-operatively. According to the results of TCD, patients were consecutively enrolled into the following three groups: normal (Group I), sclerosis (Group II); and narrow (Group III). The diagnosis of POCD was based on the criteria of the International Study of Postoperative Cognitive Dysfunction (ISPOCD) group. Neuropsychological testing was repeated 7 days post-operatively.
Results: A total of 95 patients completed the post-operative assessment on day 7. The incidence of POCD in Groups I, II, and III was 16.2%, 27.5%, and 55.6%, respectively. The incidence of POCD was significantly higher in Group III than Group I. Logistic stepwise regression analysis demonstrated that the peri-operative risk factors for POCD were cerebral artery stenosis, the operative time, and time to awakening.
Conclusion: Cerebral artery stenosis may increase the incidence of POCD in the elderly.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.
Our 7 faculties and 12 professional schools offer more than 200 programmes to some 18,000 graduate, undergraduate and continuing studies students.
The UWI, Mona ranks first in Jamaica among accredited tertiary-level programmes. In 2012, the University was again one of Jamaica’s Top 100 Employers.
