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Clinical Analysis of Neonatal Food Protein Induced Enterocolitis Syndrome in 137 Newborn Infants



Objective: To explore the clinical characters, diagnosis, therapy and prognosis of neonatal food protein induced enterocolitis syndrome (NFPIES) to provide a reference for diagnosis and treatment.

Methods: 137 newborn infants admitted to the neonatology department of our hospital between 2007 and 2012 were included in the study and an analysis of the gender, season of admission, delivery history, clinical manifestation, stool test, C Reactive Protein and application of antibiotics was performed.

Results: There was a gradual increase in morbidity, year over year, in NFPIES infants admitted to the neonatology department between 2007 and 2012. Fetal factors: Birth weight between 2.5 and 4 kgs played a significant role. NFPIES occurs between days 1 to 28 birth with a median of 16 days. The number of infants that developed NFPIES within 14 days of birth was 63 (46%). The variation of C reactive protein was between 0.15mg/l and 164mg/l (with an average of 18.82mg/l) in the 137 newborn infants in the study. 36 infants recovered without the application of antibiotics and were termed as Group A and the other 101 cases were called Group B. The duration of recovery for group A was shorter than that for Group B (p<0.05).

Conclusion: In the past 6 years, the number of NFPIES cases admitted to the neonatology department of our hospital presents a rising trend. NFPIES occurred mainly among term infants, those with mixed feeding, caesarean section and in infants with normal birth weight. The clinical manifestation of NFPIES was not typical, so the diagnosis and differential diagnosis were difficult. 

30 Mar, 2017
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e-Published: 08 May, 2017


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