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Immunohistochemical Analysis of Laryngeal Chondrosarcoma: A Case Report



Laryngeal chondrosarcoma is a rare entity, reportedly comprising less than 1% of all laryngeal tumors. Obtaining the necessary tissue for a histological examination can be difficult. Another difficult step is distinguishing a chondrosarcoma from a chondroma. This differentiation can be achieved through immunohistochemical analysis.

We present the histopathological and immunohistochemical aspects of a laryngeal chondrosarcoma, well differentiated and with low grade malignancy, located on the cricoid cartilage. Anatomopathological examination confirms the diagnosis of low-grade malignancy chondrosarcoma and CT scans show no metastasis, therefore the tumor is removed through total laryngectomy with primary pharyngeal reconstruction with a favourable evolution.

The histopathological examination used the classical Hematoxylin-Eosin technique and the immunohistochemical method was based on soluble immunoenzymatic complexes.

This is the first article in the literature that analyzes the immunohistochemical aspects of the laryngeal chondrosarcoma. We consider this study very important beacause of the high difficulty level of obtaining the necessary bioptic material and differentiating it from a laryngeal chondroma. The four antibodies we studied allow us to give the certain diagnosis of a laryngeal chondrosarcoma.

31 Mar, 2017
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e-Published: 17 May, 2017


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