Close Menu

Books in a Library

Aspirin Exacerbated Respiratory Disease and Nasal Polyps



Objective: This study estimated the prevalence of patients with aspirin exacerbated respiratory disease (AERD) in the total group of patients with chronic rhinosinusitis with nasal polyps (CHRwNP), as well as a statistically significant difference between these two groups.

Material and method: By analyzing 150 patients with diagnoses of CHRwNP, a subgroup of patients with intolerance to aspirin and other NSAIDs with asthma was isolated.

Results: Out of 150 surveyed patients 57.3% had bronchial hyperreactivity, asthma was in 39.33% of patients and 25.3% had AERD. The average age of all examined patients was 52.83 ± 12.28 years, while those with AERD were 47.24 ± 13.35. The ratio was 1: 1.7 in favor of women. At the initial endoscopic examination, 63.16 % of patients were diagnosed with second degree and 36.84% with the third degree of polyps. After a year of therapy, we registered in 2.63% of patients first degree polyps in 60.53% second and in 36.84% third degree nasal polyps. During the year, with the first adequate therapy, 26.32% of patients required another round of a systemic corticosteroid therapy and 73.68% of the patients required three therapies.

Conclusion: CHRwNP in AERD, is the most severe form of nasal polyps, with statistically significant presence of difficult forms of polyps, as well as the need for larger number of repeated rounds of systemic corticosteroids during one year and the worst result of treatment with a large number of residual polyps, as well as a statistically large number of decision on further surgical treatment.

31 Mar, 2017
e-Published: 18 May, 2017


Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.

Top of Page