Pregabalin and gabapentin, it’s pharmacological like drug are new generation antiepileptic drugs. They show their effects through voltage-gated calcium channels. Sedation and cognitive dysfunction are among their side effects. There are some investigations shows that pregabalin and gabapentin may help to quit smoking. In this article two patients are presented. One of them smoked 60 cigarettes per a day for ten years and her urge to smoke decreased after pregabalin treatment and she quitted smoking. The other one smoked 40 cigarettes per a day for 20 years and his urge to smoke decreased after gabapentin treatment and he quitted smoking. Moreover, the use of pregabalin and gabapentin in the treatment of smoking cessation is discussed through their side effects.
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