ABSTRACT
Pregabalin and gabapentin are a new-generation anti-epileptic drugs. They show their effects through voltage-gated, calcium channels. Sedation and cognitive dysfunctions are among their side effects. There are some investigations which show that pregabalin and gabapentin may help in quitting smoking. In this study, two patients are presented: one who smoked 60 cigarettes per day for 10 years and her urge to smoke decreased after pregabalin treatment and she quitted smoking; and the other who smoked 40 cigarettes per day for 20 years and his urge to smoke decreased after gabapentin treatment and he quitted smoking. The use of pregabalin and gabapentin in the treatment of smoking cessation is discussed as well as their side effects.
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