ABSTRACT
Objective: The purpose of this study was to evaluate the relation between newly diagnosed type 2 diabetes and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.
Methods: Fourty nine subjects newly diagnosed with type 2 diabetes and 37 healthy were included in the study.
Results: We found that in type 2 diabetes group, disulfide (p = 003), disulfide/native thiol (p < 0.001), disulfide/total thiol (p < 0.001), c reactive protein (p = 0.004), and erythrocyte sedimentation rate (p = 0.003) levels were higher than the control group, in type 2 diabetes group, native thiol levels (p = 0.002), total thiol levels (p = 0.016) and native thiol/total thiol ratio levels (p < 0.001) were lower than the control group. Furthermore, a negative correlation was determined between glycolysed hemoglobin, c reactive protein, erythrocyte sedimentation rateand native thiol (r = - 0.368, p = 0.017; r = - 0.477, p= 0.003; r = - 0.574, p = 0.001 respectively), total thiol levels ( r= - 0.321, p =0.038; r= - 0.402, p= 0.014; r= - 0.543, p= 0.002 respectively). High disulfide levels and low thiol levels in patients with newly diagnosed type 2 diabetes were found to be independent of sex, age, waist circumference and bmi.
Conclusion: This study shows that mechanism involving oxidative stress operates in the development of type 2 diabetes. Our study supports the hypothesis that poor glycaemic control and chronic inflammation might be the major cause of increase in oxide thiol form.
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