Objectives: The objective of the study was to evaluate the effect of induction of labour with misoprostol on the active phase of labour.
Methods: A retrospective cohort study was performed involving patients. A cohort of patients induced with misoprostol was compared to time matched control group of women who had spontaneous labour over a six month period at the University Hospital of the West Indies (UHWI). Extracted data was analysed using IBM SPSS Statistics 22.
Results: Hypertensive disorders of pregnancy, postdates, and diabetes were the most common indications for induction of labour, accounting cumulatively for 70% of the cases. Induction with misoprostol was associated with a significantly increased duration of the latent phase of labour. The rate of cervical dilatation was increased in the active phase (Mean: 2.09 vs 1.42cm/hr, p=0.059); and the duration of the active phase of labour was shorter (Mean: 5.25 vs 7.14hours, p=0.096) for women induced with misoprostol compared to controls. The duration of the second stage of labour in both groups of subjects was considerably shorter than previously described in the literature.
Conclusion: While misoprostol may be associated with an increase in the rate of cervical dilatation during active labour this was not conclusively proven by our study. Further research is needed in our population.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.