ABSTRACT
Objective: This paper aimed to study the relationships between clinical systemic lupus erythematosus (SLE) symptoms and indexes of blood, renal function, liver function and immunology.
Methods: Total 117 SLE patients were collected, and clinical symptoms and biochemical indexes of blood, renal function, liver function and immunology were determined. Then, adaptive lasso analysis was used to analyse the potential relationship between the clinical symptoms of SLE and biochemical indexes.
Results: The present results indicated that pleurisy is closely related to the red blood cells (RBC), haemoglobin (Hb) and urea nitrogen (BUN) with the |βj | values of 0.0045, 0.0168 and 0.0064, respectively; oedema is closely related to the albuminuria and cylindruria with |βj | values of 0.0198 and 0.1170; alopecia has closely correlations with liver damage and aspartate aminotransferase (AST), (|βj | values were 0.0033 and 0.0104); fever is correlated to liver damage (|βj | values were 0.0011); raynaud phenomenon is closely correlated to the triglycerides (TG) and Anti-U1 Ribonucleoprotein (u1RNP) with |βj | value of 0.0012 and 0.0012; facial redness and arthralgia have close correlations with SSA (|βj | value were 0.3580 and 0.0047; arthritis and pericarditis are closely related to anti-nucleosome antivodies (AnuA) with |βj | values of 0.0038 and 0.0026.
Conclusion: The present study indicated that some biochemical, including RBC, Hb, BUN, albuminuria and cylindruria, liver damage, AST, TG, SSA, AnuA and u1RNP, are closely to the prognosis of SLE and it’s important to control these biochemical indexes during the treatment period.
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