Hospital-acquired infections are regarded as infections that occur in hospital environment more than 48 hours after hospital admission. They may occur by transmitting the infections from the environment into the tissues where they cause inflammatory pathological process. Another way of transmitting the infections is from one's own tissues, that is, from the organism, micro-organisms commensal which reach the sterile mucous membranes resulting in inflammatory reactions. The way of spreading micro-organisms in hospital-conditions, particularly in an intensive care unit (ICU), is both primary and secondary, as well as endogenous and exogenous. The endogenous one is created by a colonization of previously sterile mucous membranes from one's own organism. They are more frequent in immuno-compromised patients.
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