ABSTRACT
Objective: Haemophilia is a congenital bleeding disorder characterized by missing partially or completely, clotting factor VIII (FVIII) for Haemophilia A (HA), or factor IX (FIX) for Haemophilia B (HB). In this study, we described the epidemiology of Martinique patients with hemophilia in a French Caribbean West Indies island with afro-Caribbean origin: these epidemiological studies had never been described before, and the associated specific mutations for the corresponding genes were unknown.
Methods: We conducted a descriptive study with the experience of the Martinique Cancer Registry and collected laboratory data with patient’s consents.
Results: Results showed that about 130 Hemophilia patients have been diagnosis in Martinique. Haemophilia A (HA) and B (HB) are represented, with a higher number of patients for HA. In 2017, three alive HA patients have inhibitors: this represents a costly complication treatment for this disease. Also, specific mutations have been found: until now, they were not referenced in international data base.
Conclusion: Until his creation in 2000, the Martinique regional center of Haemophilia treatment plays a crucial role in global care for patients harboring clotting factor deficiencies. From the experience of Martinique, it would be interesting to build a collaborative work around the diagnosis and the treatment of haemophilia in the Caribbean area, and French Guyana.
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