The Collaborative study on the Genetics of Alcoholism, Trinidad and Tobago (COGA-TT), studied the frequencies of the genes of alcohol metabolizing enzyme in a population comprising Indo-Trinbagonians (Indo-TTs) and Afro-Trinbagonians (Afro-TTs).
COGA-TT found that possession of an ADH1C*2 allele conferred greater risk of alcohol dependence and higher GGT levels than those where the allele was absent and also discovered that the ADH1B*3 allele had a protective effect against development of alcoholism. Indo-TTs with at least one ALDH1A1*2 allele had statistically significant probability of lifetime diagnosis for alcohol dependence. The results suggested a probable but not absolute predisposition to alcohol dependence in Indo-TTs and some protection in Afro-TTs.
The policy implications include those: 1. affecting the manufacture, distribution, and sale of alcohol; 2. Acceptable use of alcohol by the consumer and controlling the use of on special occasions, like Carnival; 3. controlling the promotion of the sale of alcohol to adolescents and 4. Define procedures for managing individuals who become dependent on alcohol.
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