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Collaborative Study on the Genetics of Alcoholism (COGA) in Trinidad and Tobago: Review of Findings and Implication

Journal Authors: 
DOI: 
10.7727/wimj.2017.228

ABSTRACT

The Collaborative study on the Genetics of Alcoholism, Trinidad and Tobago (COGA-TT), studied the frequencies of the genes of alcohol metabolizing enzyme in a population comprising Indo-Trinbagonians (Indo-TTs) and Afro-Trinbagonians (Afro-TTs). 

COGA-TT found that possession of an ADH1C*2 allele conferred greater risk of alcohol dependence and higher GGT levels than those where the allele was absent and also discovered that the ADH1B*3 allele had a protective effect against development of alcoholism.  Indo-TTs with at least one ALDH1A1*2 allele had  statistically significant probability of lifetime diagnosis for alcohol dependence.  The results suggested a probable but not absolute predisposition to alcohol dependence in Indo-TTs and some protection in Afro-TTs.

The policy implications include those: 1. affecting the manufacture, distribution, and sale of alcohol; 2. Acceptable use of alcohol by the consumer and controlling the use of on special occasions, like Carnival; 3. controlling the promotion of the sale of alcohol to adolescents and 4. Define procedures for managing individuals who become dependent on alcohol.

Accepted: 
18 Dec, 2017
Weight: 
0
e-Published: 20 Dec, 2017

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