Aim: To evaluate the level of mean platelet volume (MPV) and red cell distribution width (RDW) in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD) and to investigate the relationship between MPV and RDW levels with pulmonary function test (PFT), right ventricle dysfunction (RVD), arterial blood gases (ABG) and inflammatory status.
Methods: 91 patients with COPD and 50 healthy subjects were included in the study. MPV, RDW, C-reactive protein (CRP) levels and complete blood count, PFT, echocardiographic (ECHO) findings and ABG were evaluated in patients during the stable period and exacerbation.
Results: The mean MPV and RDW levels were statistically higher in both COPD group than control group (p < 0.01, for MPV; p < 0.001, for RDW, for both). There was no significant difference in mean MPV and RDW values between COPD groups (p > 0.05). There were no significant correlations between CRP, and MPV, RDW levels either in patients with stable COPD or those with exacerbation. Serum levels of MPV showed negative correlation with forced vital capacity (FVC) and pulmonary arterial oxygen pressure (PaO2) in patients with stable COPD (r= -0.400, p < 0.05 and r = -0.370, p < 0.05, respectively) and there was a negative correlation between MPV levels and forced expiratory volume in 1 second (FEV1) in patients with COPD exacerbation (r= -0.294, p < 0.05).
Conclusions: Our results showed that MPV and RDW levels increased in both acute exacerbation and stable COPD patients. In addition, MPV may be related with respiratory function loss and hypoxia than inflammation in COPD patients.
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