ABSTRACT
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that results from the deficiency of one of several steroidogenic pathways in cortisol synthesis. The worldwide incidence of classic CAH (21 hydroxylase deficiency) is between 1:15 000 and 1:16 000 in Europe and North America and 1:19 000 in Japan, with the non-classic type at 1:1000(1).Classic CAH accounts for 90% of cases due to mutations or deletions in the CYP21A gene(1). In managing any neonate with ambiguous genitalia, CAH is a very important differential diagnosis as it has significant implications for future development, even gender assignment. The challenge of diagnosing CAH is compounded by prematurity associated factors that can lead to misinterpretation of traditional target levels for 17 hydroxyprogesterone (17-OHP), stress induced alterations in 17-OHP values and lack of population-based reference values especially at lower gestational ages.
Manuscripts that are Published Ahead of Print have been peer reviewed and accepted for publication by the Editorial Board of the West Indian Medical Journal. They may appear in their original format and may not be copy edited or formatted in the style guide of this Journal. While accepted manuscripts are not yet assigned a volume, issue or page numbers, they can be cited using the DOI and date of e-publication. See our Instructions for Authors on how to properly cite manuscripts at this stage. The contents of the manuscript may change before it is published in its final form. Manuscripts in this section will be removed once they have been issued to a volume and issue, but will still retain the DOI and date of e-publication.
Our 7 faculties and 12 professional schools offer more than 200 programmes to some 18,000 graduate, undergraduate and continuing studies students.
The UWI, Mona ranks first in Jamaica among accredited tertiary-level programmes. In 2012, the University was again one of Jamaica’s Top 100 Employers.
