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Simple Inflammatory Markers for the Early Diagnosis of Celiac Disease



Objective: The aim is to compare the newly diagnosed Celiac and control groups in terms of inflammatory markers such as platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR).

Methods: This retrospective study included 68 patients who were newly diagnosed with Celiac Disease (CD) and 30 healthy volunteers. Haemogram tests and C-reactive protein (CRP) measurements were obtained from the hospital records. Then, NLR and PLR were calculated.

Kolmogorov-Smirnov test, Student’s t-test, Mann-Whitney U-test, then Pearson’s or Spearman’s correlation analysis were used. Receiver operating characteristic (ROC) analyses were performed. Local Ethics Committee for Clinical Research approved this study.

Results: The mean ± SD values of NLR (1.98 ± 1.02, 2.54 ± 1.28), PLR (114.56 ± 40.61, 158.31 ± 62.86), mean platelet volume (MPV) [8.26 ± 0.84, 7.76 ± 1.55], mean corpuscular haemoglobin concentration (MCHC) [34.36 ± 0.68, 33.04 ± 1.63] and red cell distribution width (RDW) [13.42 ± 1.01, 13.25 ± 2.71] were significantly different between healthy and newly diagnosed CD groups (p < 0.01).  In ROC analysis, NLR ≥ 1.58 had 97.1% sensitivity and 55.2% specificity, PLR ≥ 110.69 had 80% sensitivity and 59% specificity, RDW ≤ 13.25 had 67.6% sensitivity and 56% specificity in predicting newly diagnosed CD.

Conclusion: Neutrophil/lymphocyte ratio, PLR, RDW, MPV and MCHC are significantly different in newly diagnosed CD (p < 0.01). Platelet/lymphocyte ratio is correlated positively with NLR and RDW; negatively with, MPV and MCHC (p < 0.01). Neutrophil/lymphocyte ratio, PLR and RDW may be early clues to the diagnosis of CD.

22 Mar, 2018
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e-Published: 08 Jul, 2019


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